Treat of Urological disease with :- Prostate Cancer Approximately 90% of prostate cancers are diagnosed at a localized stage (cancer confined to prostate without evidence of spread). Localized cancers are most commonly detected through an elevation in PSA without causing symptoms. Less commonly, prostate cancer may be detected by an abnormal digital rectal exam (DRE) or due to urinary symptoms, such as hematuria (blood in the urine) or problems with urination (difficulty or discomfort with urination). Not all local prostate cancers are the same. Some are indolent and will not cause problems while others are clinically significant and require treatment. Even among clinically significant cancers, there are differences that further separate cancers by risk (for example, low, intermediate and high risk prostate cancer). Factors that determine the risk and clinical significance of prostate cancer include PSA, Gleason grade and disease stage. There are several effective treatment options for men with clinically significant local prostate cancer, including surgery, external radiation therapy and interstitial brachytherapy. Treatment recommendations are usually made based on a number of factors, including disease characteristics, risk category, candidacy for a particular treatment, and patient preference. In some cases (low- and intermediate-risk prostate cancer, for example), a single treatment may be adequate for disease control. For others, particularly in high-risk prostate cancer, a combination of treatments may be required. For low-risk prostate cancer and among older men, active-surveillance (observation) is another management option. Although effective in cancer control, most prostate cancer treatments carry some risk of impacting urinary, sexual and bowel health. Newer treatment methods, however, continue to be developed to minimize the risks of these side effects (for example, nerve-sparing radical prostatectomy). Following treatment, approximately 15% to 25% of patients with early-stage (localized) prostate cancer experience a biochemical (PSA) recurrence, indicating possible need for additional therapy. However, the overall 5-year survival for patients with localized prostate cancer is close to 100%.